The NET Alliance™ and Novartis Oncology continue their commitment to improving knowledge and management of neuroendocrine tumors, and empowering patients to be more informed advocates.

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Accurate analysis of NET pathology

Accurate, detailed pathology reporting is necessary for definitive identification and confirmation of a neuroendocrine tumor (NET).

Pathologically speaking, NET are defined as epithelial neoplasms with predominant neuroendocrine differentiation.32 Essentially, NET constitute a broad spectrum of biologically different neoplasms. However, despite this variability, many NET have remarkably similar pathologic features, rendering their distinction and identification challenging to pathologists.4,32,33

Because the optimal management of patients with NET involves multiple specialists,33 pathology reports for NET should contain certain information that facilitates effective decision-making by all members of the management team.32

A NET pathology report should include these 7 elements32:

  1. Site and diagnosis
  2. Stage
  3. Differentiation
  4. Grade, proliferative rate, and mitotic rate
  5. Other prognostic factors, such as necrosis or vascular invasion
  6. Non–NET-related components
  7. Status of margins